Search results for " Etiology"

Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients

2019

The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. While defects in lipid antigen presentation and in invariant Natural Killer T (iNKT) cell response were detected in several mouse models of lysosomal storage diseases (LSD), the impact of lysosomal engorgement in human lipid antigen presentation is poorly characterized. Here, we analyzed the capacity of monocyte-derived dendritic cells (Mo-DCs) from Fabry, Gaucher, Niemann Pick type C and Mucopolysaccharidosis type VI disease patients to present exogenous antigens to lipid-specific T cells. The CD1b- and CD1d-restricted presentation of lipid antigens by Mo-DCs revealed an ability of LSD patients to induce CD…

Kawasaki disease epidemic: pitfalls

2020

AbstractRecent reports have described in the pediatric population a new type of hyperinflammatory response manifested following contact with SARS-CoV-2, with some of the clinical features attributable to Kawasaki disease (KD). The purpose of this commentary is to remark on a possible recent association between SARS-CoV-2 and KD. Although today little is known about the etiology of KD, the most accepted hypothesis is that of a probable viral etiology, therefore, even the SARS-CoV-2 virus could trigger, in genetically predisposed subjects, an exaggerated inflammatory response that is clinically evident like the one described in KD.

Histological findings in direct inguinal hernia

2013

Abstract BACKGROUND: The study is focused on recognizing the histological changes of the structures close to and around the hernia opening in patients having direct inguinal hernia. METHODS: In 15 patients with primary bilateral direct inguinal hernia who underwent a Stoppa open posterior inguinal hernia repair, tissue specimens from the abdominal wall surrounding a direct hernia border were excised for histological examination. These findings in patients with direct inguinal hernia were compared with tissue specimens excised from the fossa inguinalis media of cadavers without hernia. RESULTS: Significant degenerative modifications such as fibrohyaline degeneration and fatty substitution of…

Multifocal epithelial hyperplasia, a rare oral infection in Asia : report of twelve cases in Iran

2009

Objectives: Multifocal epithelial hyperplasia (MEH) is benign, asymptomatic oral disease with viral etiology. The frequency of this disease varies widely from one geographic region to another, and can vary, from 0.002 to 35% depending on the population studied. Study design: Here we report the clinicopathological features of twelve cases of MEH referred to Oral Medicine Department of Mashhad Dental School for the first time in Iran. Records of patients with the diagnosis of MEH in our department during 7 years were analyzed and data were extracted. Results: Most of the patients were younger than 20-year-old (66%), and females were predominantly affected (7:12). The mean age of onset was 12.…

DMFT indekss un kariesa izplatība Latvijas Universitātes studentu zobārstniecības klīnikas pacientiem

2022

Mutes veselībai ir ļoti nozīmīgs iedzīvotāju labklājības faktors. Slikta mutes dobuma veselība var būt par iemeslu sāpēm, zobu zaudējumam, funkciju zudumumam un pazeminātai pašcieņai. Zobu kariess ir viena no divām visbiežāk sastopamajām mutes dobuma saslimšanām un zobu zaudējuma iemesliem. Epidemioloģiskie pētījumi, izmantojot dažādus starptautiski pieņemtus indeksus, lēš, ka globāli neārstēts kariess pastāvīgo zobos ir 2,3 miljardiem cilvēku un neārstēts kariess piena zobos - 532 miljoniem bērnu. Taču pētījumu pieaugušajiem ir daudz mazāk nekā bērniem, kas arī pamato darba mērķi - analizēt DMFT indeksu un kariesa izplatību pieaugušiem pacientiem, kuri apmeklē Latvijas Universitātes Studen…

Paper 6: EUROCAT member registries: organization and activities.

2011

BACKGROUND: EUROCAT is a network of population-based congenital anomaly registries providing standardized epidemiologic information on congenital anomalies in Europe. There are three types of EUROCAT membership: full, associate, or affiliate. Full member registries send individual records of all congenital anomalies covered by their region. Associate members transmit aggregate case counts for each EUROCAT anomaly subgroup by year and by type of birth. This article describes the organization and activities of each of the current 29 full member and 6 associate member registries of EUROCAT. METHODS: Each registry description provides information on the history and funding of the registry, popu…

The metabolic syndrome-arterial stiffness relationship in patients with ischaemic stroke: role of inflammation

2008

Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene

2015

International audience; Here we describe a spontaneous mutation in the Zdhhc13 (zinc finger, DHHC domain containing 13) gene (also called Hip14l), one of 24 genes encoding palmitoyl acyltransferase (PAT) enzymes in the mouse. This mutation (Zdhhc13luc) was identified as a nonsense base substitution, which results in a premature stop codon that generates a truncated form of the ZDHHC13 protein, representing a potential loss-of-function allele. Homozygous Zdhhc13luc/Zdhhc13luc mice developed generalized hypotrichosis, associated with abnormal hair cycle, epidermal and sebaceous gland hyperplasia, hyperkeratosis, and increased epidermal thickness. Increased keratinocyte proliferation and accel…

Phytopathogenic Bacteria Associated with Bacterioses of Common Oak (Quercus robur L.) in Ukraine

2022

Studying the biological characteristics of the causative agents of bacteriosis of the common oak (Quercus robur L.) (to highlight the links between the key factors of pathogenesis and bacterial groups) is a new and relevant area of research. This work aims to identify the species composition of phytopathogenic bacteria associated with common oak bacteriosis and to study the morphological, cultural, and biochemical properties of pathogens. To establish the general phytosanitary state of the surveyed stands, classical forest inventory and phytopathological (visual on based on typical symptoms of the disease and macroscopic) methods were used. The properties of isolated bacteria were studied u…

Validation of the Beliefs about Children's Adjustment in Same-Sex Families Scale in Italian University Students.

2019

Assessing attitudes toward same-sex parenting has important implications for both intervention and prevention programs designed to foster the tolerance and normality of sexual and family diversity. Few empirically validated measures of rejection of same-sex parenting have been developed. The current study examined the psychometric properties of an Italian translation of the Beliefs about Children's Adjustment in Same-Sex Families Scale, a 14-item scale distributed in two subscales that measure direct and subtle rejection toward same-sex parenting, for its use in assessing heterosexual people's attitudes toward same-sex parents in Italy. The sample consisted of 344 Italian heterosexual unive…